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EBNA-3a–deficient LCLs proliferate additional slowly and gradually and show amplified apoptosis when compared to wild-type virus–derived LCLs.
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Between these latency proteins, EBNA-3a plays a supportive but non-essential job in B cell transformation: EBV mutants missing EBNA-3a can still remodel B cells, but with considerably reduced effectiveness.
Rewards involve resistance to dewetting, compatibility with 100% aqueous mobile phases, substitute selectivity to HALO C18 and extended retention of polar compounds than classic C18 phases beneath most cellular stage problems.
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